4KTT

Structural insights of MAT enzymes: MATa2b complexed with SAM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	S-adenosylmethionine synthase isoform type-2	polymer	396	43807.7	4	UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773)	Homo sapiens (human)	AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2, Methionine adenosyltransferase II, MAT-II
2	E, F (E, F)	Methionine adenosyltransferase 2 subunit beta	polymer	327	36862.8	2	UniProt (Q9NZL9) Pfam (PF04321)	Homo sapiens (human)	Methionine adenosyltransferase II beta, MAT II beta, Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
3	BA, CA, DA, EA, FA... (D, A, E, B, F...)	1,2-ETHANEDIOL	non-polymer		62.1	28	Chemie (EDO)
4	K, Z (A, C)	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (9865603) PubChem (12312798) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (145712080) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094)
5	AA, L (C, A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4) PubChem (1061)
6	V (B)	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG) PubChem (888)
7	NA, OA, PA, QA, RA... (A, B, C, D, E...)	water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 395 (UniProt: P31153)

PDB	External Database	Details
Ser 0	-	expression tag

E, F: 9 - 323 (UniProt: Q9NZL9)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	248956.5
Non-Polymers*	Number of molecules	33
	Total formula weight	2749.0
All*	Total formula weight	251705.5

*Water molecules are not included.