4KTT

Structural insights of MAT enzymes: MATa2b complexed with SAM

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	S-adenosylmethionine synthase isoform type-2	polymer	396	43807.7	4	UniProt (P31153) Pfam (PF00438) Pfam (PF02772) Pfam (PF02773) In PDB	Homo sapiens (human)	AdoMet synthase 2, Methionine adenosyltransferase 2, MAT 2, Methionine adenosyltransferase II, MAT-II
2	E, F	Methionine adenosyltransferase 2 subunit beta	polymer	327	36862.8	2	UniProt (Q9NZL9) Pfam (PF04321) In PDB	Homo sapiens (human)	Methionine adenosyltransferase II beta, MAT II beta, Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
3	D, A, E, B, F...	1,2-ETHANEDIOL	non-polymer		62.1	28	Chemie (EDO)
4	A, C	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)
5	C, A	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
6	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
7		water	water		18.0	108	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 395 (UniProt: P31153)

PDB	External Database	Details
Ser 0	-	expression tag

E, F: 9 - 323 (UniProt: Q9NZL9)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Met 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	248956.5
Non-Polymers*	Number of molecules	33
	Total formula weight	2749.0
All*	Total formula weight	251705.5

*Water molecules are not included.