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4KPD

Crystal Structure of Human Farnesyl Pyrophosphate Synthase (Y204F) Mutant Complexed with Mg, Risedronate and Isopentenyl Pyrophosphate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Farnesyl pyrophosphate synthasepolymer37543129.01UniProt (P14324)
Pfam (PF00348)
Homo sapiens (human)FPP synthase, FPS, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, Farnesyl diphosphate synthase, Geranyltranstransferase
2B, C, D
(A)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
3E
(A)
3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATEnon-polymer246.11Chemie (IPE)
4F
(A)
1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACIDnon-polymer283.11Chemie (RIS)
5G
(A)
waterwater18.0161Chemie (HOH)
Sequence modifications
A: 1 - 353 (UniProt: P14324)
PDBExternal DatabaseDetails
Met -21-expression tag
Gly -20-expression tag
Ser -19-expression tag
Ser -18-expression tag
His -17-expression tag
His -16-expression tag
His -15-expression tag
His -14-expression tag
His -13-expression tag
His -12-expression tag
Ser -11-expression tag
Ser -10-expression tag
Gly -9-expression tag
Arg -8-expression tag
Glu -7-expression tag
Asn -6-expression tag
Leu -5-expression tag
Tyr -4-expression tag
Phe -3-expression tag
Gln -2-expression tag
Gly -1-expression tag
His 0-expression tag
Phe 204Tyr 270engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight43129.0
Non-Polymers*Number of molecules5
Total formula weight602.1
All*Total formula weight43731.1
*Water molecules are not included.

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PDB entries from 2024-11-13

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