4KP6
Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | polymer | 340 | 39034.2 | 1 | UniProt (Q07343) Pfam (PF00233) | Homo sapiens (human) | DPDE4, PDE32 |
| 2 | B (A) | 2-ethyl-2-{[4-(methylamino)-6-(1H-1,2,4-triazol-1-yl)-1,3,5-triazin-2-yl]amino}butanenitrile | non-polymer | 287.3 | 1 | Chemie (1S1) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F, G, H, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 19 | Chemie (EDO) | |||
| 6 | X (A) | water | water | 18.0 | 151 | Chemie (HOH) |
Sequence modifications
A: 152 - 487 (UniProt: Q07343)
| PDB | External Database | Details |
|---|---|---|
| Gly 148 | - | expression tag |
| Ala 149 | - | expression tag |
| Met 150 | - | expression tag |
| Gly 151 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39034.2 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 1556.3 | |
| All* | Total formula weight | 40590.5 |
