4KN2
Human folate receptor beta (FOLR2) in complex with antifolate pemetrexed
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Folate receptor beta | polymer | 207 | 24022.0 | 3 | UniProt (P14207) Pfam (PF03024) | Homo sapiens (human) | FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP |
| 2 | D, H, L (A, B, C) | POTASSIUM ION | non-polymer | 39.1 | 3 | Chemie (K) | |||
| 3 | E, I, M (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | F, J, N (A, B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 5 | G, K, O (A, B, C) | 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID | non-polymer | 427.4 | 3 | Chemie (LYA) | |||
| 6 | P, Q, R (A, B, C) | water | water | 18.0 | 115 | Chemie (HOH) |
Sequence modifications
A, B, C: 24 - 227 (UniProt: P14207)
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Ser 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 72066.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2169.5 | |
| All* | Total formula weight | 74235.5 |
