4KN0
Human folate receptor beta (FOLR2) in complex with the antifolate methotrexate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Folate receptor beta | polymer | 207 | 24022.0 | 1 | UniProt (P14207) Pfam (PF03024) | Homo sapiens (human) | FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP |
| 2 | B, C (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D (A) | METHOTREXATE | non-polymer | 454.4 | 1 | Chemie (MTX) | |||
| 4 | E (A) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | F, G (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | H (A) | water | water | 18.0 | 228 | Chemie (HOH) |
Sequence modifications
A: 24 - 228 (UniProt: P14207)
| PDB | External Database | Details |
|---|---|---|
| Gly 22 | - | expression tag |
| Ser 23 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24022.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 564.4 | |
| All* | Total formula weight | 25435.2 |
