4KMP
Structure of XIAP-BIR3 and inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | E3 ubiquitin-protein ligase XIAP | polymer | 98 | 11309.7 | 2 | UniProt (P98170) Pfam (PF00653) In PDB | Homo sapiens (human) | Baculoviral IAP repeat-containing protein 4, IAP-like protein, ILP, hILP, Inhibitor of apoptosis protein 3, IAP-3, hIAP-3, hIAP3, X-linked inhibitor of apoptosis protein, X-linked IAP |
| 2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | B | (2S,2'S)-N,N'-[(6,6'-difluoro-1H,1'H-2,2'-biindole-3,3'-diyl)bis{methanediyl[(2R,4S)-4-hydroxypyrrolidine-2,1-diyl][(2S)-1-oxobutane-1,2-diyl]}]bis[2-(methylamino)propanamide] | non-polymer | 806.9 | 1 | Chemie (GT6) | |||
| 4 | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A, B: 256 - 348 (UniProt: P98170)
| PDB | External Database | Details |
|---|---|---|
| Ala 251 | - | expression tag |
| Asp 252 | - | expression tag |
| Ser 253 | - | expression tag |
| His 254 | - | expression tag |
| Met 255 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 22619.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 937.8 | |
| All* | Total formula weight | 23557.1 |
