4KLA
E343D variant of human ferrochelatase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Ferrochelatase, mitochondrial | polymer | 359 | 41164.4 | 2 | UniProt (P22830) Pfam (PF00762) | Homo sapiens (human) | Heme synthase, Protoheme ferro-lyase |
| 2 | C, D, G (A, B) | CHOLIC ACID | non-polymer | 408.6 | 3 | Chemie (CHD) | |||
| 3 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, I (A, B) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 5 | H (B) | PROTOPORPHYRIN IX | non-polymer | 562.7 | 1 | Chemie (PP9) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A, B: 65 - 423 (UniProt: P22830)
| PDB | External Database | Details |
|---|---|---|
| Asp 343 | Glu 343 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 82328.7 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2232.1 | |
| All* | Total formula weight | 84560.8 |
