4KIT
Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | U5 small nuclear ribonucleoprotein 200 kDa helicase | polymer | 1739 | 198785.8 | 1 | UniProt (O75643) Pfam (PF00270) Pfam (PF00271) Pfam (PF02889) | Homo sapiens (human) | Brr2 protein, Activating signal cointegrator 1 complex subunit 3-like 1, BRR2 homolog, U5 snRNP-specific 200 kDa protein, U5-200KD |
| 2 | B (C) | Pre-mRNA-processing-splicing factor 8 | polymer | 278 | 31861.0 | 1 | UniProt (Q6P2Q9) Pfam (PF01398) Pfam (PF08084) | Homo sapiens (human) | Prp8 protein, 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220 |
| 3 | C, D (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 4 | E (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
B: 395 - 2129 (UniProt: O75643)
C: 2064 - 2335 (UniProt: Q6P2Q9)
| PDB | External Database | Details |
|---|---|---|
| Gly 391 | - | expression tag |
| Ala 392 | - | expression tag |
| Glu 393 | - | expression tag |
| Phe 394 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 2058 | - | expression tag |
| Pro 2059 | - | expression tag |
| Leu 2060 | - | expression tag |
| Gly 2061 | - | expression tag |
| Ser 2062 | - | expression tag |
| Met 2063 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 230646.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 878.7 | |
| All* | Total formula weight | 231525.5 |
