4KIQ
Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Mitogen-activated protein kinase 14 | polymer | 366 | 42105.0 | 4 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | MAP kinase 14, MAPK 14, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAP kinase MXI2, MAX-interacting protein 2, Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Stress-activated protein kinase 2a, SAPK2a |
2 | A, B, C, D | ethyl 6-{[5-(cyclopropylcarbamoyl)-2-methylphenyl]carbamoyl}-1H-indole-1-carboxylate | non-polymer | 405.4 | 4 | Chemie (1RA) | |||
3 | water | water | 18.0 | 453 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Met -5 | - | expression tag |
Ala -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 168420.0 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1621.8 | |
All* | Total formula weight | 170041.8 |