4KGL
Crystal structure of human alpha-L-iduronidase complex with [2R,3R,4R,5S]-2-carboxy-3,4,5-trihydroxy-piperidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Alpha-L-iduronidase | polymer | 627 | 70053.3 | 2 | UniProt (P35475) Pfam (PF01229) Pfam (PF21200) | Homo sapiens (human) | |
| 2 | C, E (C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 3 | D (D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 4 | F (F) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G83161QT) | |||
| 5 | G, J (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | H, K, L, M, N (A, B) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) PubChem (753) | |||
| 7 | I, P (A, B) | (2R,3R,4R,5S)-3,4,5-trihydroxypiperidine-2-carboxylic acid | non-polymer | 177.2 | 2 | Chemie (IDJ) PubChem (20821664) PubChem (44561633) PubChem (44561634) PubChem (44561672) PubChem (44561780) PubChem (44561781) PubChem (44561782) PubChem (44561783) PubChem (44561784) PubChem (44561785) PubChem (452015) PubChem (58111753) PubChem (68243331) PubChem (88977959) PubChem (9815382) PubChem (11008471) PubChem (15599232) PubChem (15599233) PubChem (121373894) PubChem (123174869) PubChem (143850490) | |||
| 8 | O (B) | L(+)-TARTARIC ACID | non-polymer | 150.1 | 1 | Chemie (TLA) PubChem (875) PubChem (5851) PubChem (78956) PubChem (439655) PubChem (444305) PubChem (447315) | |||
| 9 | Q, R (A, B) | water | water | 18.0 | 54 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 653 (UniProt: P35475)
| PDB | External Database | Details |
|---|---|---|
| Gln 33 | His 33 | SEE REMARK 999 |
| Pro 63 | Gln 63 | SEE REMARK 999 |
| Gln 105 | Arg 105 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 140106.6 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 3319.0 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1407.3 | |
| All* | Total formula weight | 144832.9 |
