4KGJ
Crystal structure of human alpha-L-iduronidase complex with 5-fluoro-alpha-L-idopyranosyluronic acid fluoride
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Alpha-L-iduronidase | polymer | 627 | 70053.3 | 2 | UniProt (P35475) Pfam (PF01229) Pfam (PF21200) In PDB | Homo sapiens (human) | |
2 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | D | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
4 | F | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G83161QT) | |||
5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
6 | A, B | GLYCEROL | non-polymer | 92.1 | 7 | Chemie (GOL) | |||
7 | A, B | 5-fluoro-alpha-L-idopyranosyluronic acid fluoride | non-polymer | 214.1 | 2 | Chemie (IDF) | |||
8 | B | L(+)-TARTARIC ACID | non-polymer | 150.1 | 2 | Chemie (TLA) | |||
9 | B | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
10 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 653 (UniProt: P35475)
PDB | External Database | Details |
---|---|---|
Gln 33 | His 33 | SEE REMARK 999 |
Pro 63 | Gln 63 | SEE REMARK 999 |
Gln 105 | Arg 105 | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 140106.6 | |
Branched | Number of molecules | 4 |
Total formula weight | 3319.0 | |
Non-Polymers* | Number of molecules | 14 |
Total formula weight | 1850.9 | |
All* | Total formula weight | 145276.6 |