4KGG

Crystal structure of light mutant2 and dcr3 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (C, D)	Tumor necrosis factor receptor superfamily member 6B	polymer	174	19044.2	2	UniProt (O95407) Pfam (PF00020)	Homo sapiens (human)	Decoy receptor 3, DcR3, Decoy receptor for Fas ligand, M68
2	C, D (A, B)	Tumor necrosis factor ligand superfamily member 14	polymer	158	17208.4	2	UniProt (O43557) Pfam (PF00229)	Homo sapiens (human)	Herpes virus entry mediator ligand, HVEM-L, Herpesvirus entry mediator ligand, Tumor necrosis factor ligand superfamily member 14, membrane form, Tumor necrosis factor ligand superfamily member 14, soluble form
3	E (E)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
4	F (F)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	G, H (C, D)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	I, J, K, L (C, D, A, B)	water	water		18.0	45	Chemie (HOH)

Sequence modifications

C, D: 30 - 195 (UniProt: O95407)

PDB	External Database	Details
Thr 196	-	expression tag
Gly 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
His 203	-	expression tag

A, B: 83 - 240 (UniProt: O43557)

PDB	External Database	Details
Ser 195	Arg 195	engineered mutation
Asn 196	Val 196	engineered mutation
Phe 198	Trp 198	engineered mutation
Glu 214	Lys 214	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	72505.3
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	2
	Total formula weight	48.6
All*	Total formula weight	73727.0

*Water molecules are not included.