4KFJ
Human dihydrofolate reductase complexed with NADPH and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimidine-2,4-diamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 186 | 21349.5 | 2 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (Human) | |
| 2 | C, I (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D (A) | 6-ethyl-5-{3-[3-(isoquinolin-5-yl)-5-methoxyphenyl]prop-1-yn-1-yl}pyrimidine-2,4-diamine | non-polymer | 409.5 | 1 | Chemie (1R0) | |||
| 4 | E, H, K, M, N (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) | |||
| 5 | F, L (A, B) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | G (A) | ETHANOL | non-polymer | 46.1 | 1 | Chemie (EOH) | |||
| 7 | J (B) | FOLIC ACID | non-polymer | 441.4 | 1 | Chemie (FOL) | |||
| 8 | O, P (A, B) | water | water | 18.0 | 386 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42699.1 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 2580.2 | |
| All* | Total formula weight | 45279.3 |
