4KDO
Crystal structure of the hemagglutinin of ferret-transmissible H5N1 virus in complex with human receptor analog LSTc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, E) | Hemagglutinin | polymer | 322 | 36447.4 | 3 | UniProt (Q6DQ33) Pfam (PF00509) | Influenza A virus | |
| 2 | D, E, F (B, D, F) | Hemagglutinin | polymer | 175 | 20170.2 | 3 | UniProt (Q6DQ33) Pfam (PF00509) | Influenza A virus | |
| 3 | G, H, J (G, H, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 4 | I (I) | N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 674.6 | 1 | In PDB BIRD (PRD_900046) GlyTouCan (G73578JC) | 6'-sialyl-N-acetyllactosamine | ||
| 5 | K (A) | N-acetyl-alpha-neuraminic acid | non-polymer | 309.3 | 1 | Chemie (SIA) | |||
| 6 | L (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | M, N, O, P, Q... (A, C, E, B, D...) | water | water | 18.0 | 283 | Chemie (HOH) |
Sequence modifications
A, C, E: 5 - 325 (UniProt: Q6DQ33)
| PDB | External Database | Details |
|---|---|---|
| Gln 4 | - | expression tag |
| Asp 158 | Asn 170 | engineered mutation |
| Lys 224 | Asn 236 | engineered mutation |
| Leu 226 | Gln 238 | engineered mutation |
| Ile 319 | Thr 331 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 169852.8 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1947.8 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 530.5 | |
| All* | Total formula weight | 172331.1 |
