4KCP
Structure of bovine endotheial nitric oxide synthase heme domain in complex with N-(4-(2-((3-(thiophene-2-carboximidamido)benzyl)amino)ethyl)phenyl)thiophene-2-carboximidamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nitric oxide synthase, endothelial | polymer | 443 | 49727.0 | 2 | UniProt (P29473) Pfam (PF02898) | Bos taurus (bovine) | Constitutive NOS, cNOS, EC-NOS, Endothelial NOS, eNOS, NOS type III, NOSIII |
| 2 | C, J (A, B) | PROTOPORPHYRIN IX CONTAINING FE | non-polymer | 616.5 | 2 | Chemie (HEM) | |||
| 3 | D, K (A, B) | 5,6,7,8-TETRAHYDROBIOPTERIN | non-polymer | 241.2 | 2 | Chemie (H4B) | |||
| 4 | E, L (A, B) | N-(4-{2-[(3-{[(E)-imino(thiophen-2-yl)methyl]amino}benzyl)amino]ethyl}phenyl)thiophene-2-carboximidamide | non-polymer | 459.6 | 2 | Chemie (H44) | |||
| 5 | F, G, M, N (A, B) | ACETATE ION | non-polymer | 59.0 | 4 | Chemie (ACT) | |||
| 6 | H, O (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | I (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 8 | P, Q (A, B) | water | water | 18.0 | 302 | Chemie (HOH) |
Sequence modifications
A, B: 40 - 482 (UniProt: P29473)
| PDB | External Database | Details |
|---|---|---|
| Arg 100 | Cys 100 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 99454.0 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3120.5 | |
| All* | Total formula weight | 102574.5 |
