4KAK
Crystal structure of human dihydrofolate reductase complexed with NADPH and 6-ethyl-5-[(3S)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (UCP1006)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Dihydrofolate reductase | polymer | 186 | 21349.5 | 2 | UniProt (P00374) Pfam (PF00186) | Homo sapiens (human) | |
| 2 | C, I (A, B) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 2 | Chemie (NDP) | |||
| 3 | D, J (A, B) | 6-ethyl-5-{(3R)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl}pyrimidine-2,4-diamine | non-polymer | 373.5 | 2 | Chemie (06U) | |||
| 4 | E, F, G, K, L (A, B) | ETHANOL | non-polymer | 46.1 | 5 | Chemie (EOH) | |||
| 5 | H, M, N, O (A, B) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | P, Q (A, B) | water | water | 18.0 | 347 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42699.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2628.4 | |
| All* | Total formula weight | 45327.4 |
