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4K9B

Structure of Ternary Complex of cGAS with dsDNA and Bound c[G(2 ,5 )pA(3 ,5 )p]

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ACyclic GMP-AMP synthasepolymer36242512.11UniProt (Q8C6L5)
Pfam (PF03281)
Pfam (PF20266)
In PDB
Mus musculus (mouse)cGAMP synthase, cGAS, m-cGAS, Mab-21 domain-containing protein 1
2DDNA-Fpolymer175253.51
3EDNA-Rpolymer175159.31
4AZINC IONnon-polymer65.41Chemie (ZN)
5APHOSPHATE IONnon-polymer95.01Chemie (PO4)
6AGUANOSINE-5'-MONOPHOSPHATEnon-polymer363.21Chemie (5GP)
7AADENOSINE MONOPHOSPHATEnon-polymer347.21Chemie (AMP)
8waterwater18.0165Chemie (HOH)
Sequence modifications
A: 147 - 507 (UniProt: Q8C6L5)
PDBExternal DatabaseDetails
Ser 146-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight52924.9
Non-Polymers*Number of molecules4
Total formula weight870.8
All*Total formula weight53795.7
*Water molecules are not included.

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PDB entries from 2024-08-28

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