4K9A
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pG(2 ,5 )pA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 362 | 42512.1 | 1 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (mouse) | cGAMP synthase, cGAS, m-cGAS, Mab-21 domain-containing protein 1 |
| 2 | B (D) | DNA-F | polymer | 17 | 5253.5 | 1 | |||
| 3 | C (E) | DNA-R | polymer | 17 | 5159.3 | 1 | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E (A) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 6 | F (A) | GUANOSINE-5'-MONOPHOSPHATE | non-polymer | 363.2 | 1 | Chemie (5GP) | |||
| 7 | G (A) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (6083) PubChem (224) PubChem (162290139) PubChem (638042) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (1549371) PubChem (5316444) PubChem (5742864) PubChem (122197642) PubChem (12358354) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40459109) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (46875232) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (162946266) PubChem (171699505) PubChem (12163610) PubChem (92144436) PubChem (45358029) PubChem (46874558) | |||
| 8 | H, I, J (A, D, E) | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 52924.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 870.8 | |
| All* | Total formula weight | 53795.7 |
