4K99
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 362 | 42512.1 | 1 | UniProt (Q8C6L5) Pfam (PF03281) Pfam (PF20266) | Mus musculus (mouse) | cGAMP synthase, cGAS, m-cGAS, Mab-21 domain-containing protein 1 |
| 2 | B (D) | DNA-F | polymer | 17 | 5253.5 | 1 | |||
| 3 | C (E) | DNA-R | polymer | 17 | 5159.3 | 1 | |||
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | G (A) | 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (GH3) | |||
| 7 | H (A) | 3'-deoxy-guanosine 5'-monophosphate | non-polymer | 347.2 | 1 | Chemie (GDO) | |||
| 8 | I, J, K (A, D, E) | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
A: 147 - 507 (UniProt: Q8C6L5)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 52924.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 968.4 | |
| All* | Total formula weight | 53893.3 |
