4K8R
An Antibody Against the C-terminal Domain of PCSK9 lowers LDL Cholesterol Levels in vivo
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Proprotein convertase subtilisin/kexin type 9 | polymer | 92 | 10490.1 | 1 | UniProt (Q8NBP7) Pfam (PF05922) | Homo sapiens (human) | Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9 |
| 2 | B (B) | Proprotein convertase subtilisin/kexin type 9 | polymer | 548 | 58514.9 | 1 | UniProt (Q8NBP7) Pfam (PF00082) Pfam (PF18459) Pfam (PF18464) Pfam (PF18463) | Homo sapiens (human) | Neural apoptosis-regulated convertase 1, NARC-1, Proprotein convertase 9, PC9, Subtilisin/kexin-like protease PC9 |
| 3 | C (C) | Fab1, light chain | polymer | 214 | 23248.8 | 1 | Homo sapiens (human) | ||
| 4 | D (D) | Fab1, heavy chain | polymer | 234 | 24877.5 | 1 | Homo sapiens (human) | ||
| 5 | E (H) | Fab3H42, heavy chain | polymer | 238 | 25489.3 | 1 | Homo sapiens (human) | ||
| 6 | F (L) | Fab3H42, light chain | polymer | 217 | 22626.9 | 1 | Homo sapiens (human) | ||
| 7 | G, H, I, J, K... (A, B, C, D, H...) | water | water | 18.0 | 282 | Chemie (HOH) |
Sequence modifications
B: 153 - 692 (UniProt: Q8NBP7)
| PDB | External Database | Details |
|---|---|---|
| Ile 474 | Val 474 | engineered mutation |
| Glu 670 | Gly 670 | engineered mutation |
| Leu 693 | - | expression tag |
| Glu 694 | - | expression tag |
| His 695 | - | expression tag |
| His 696 | - | expression tag |
| His 697 | - | expression tag |
| His 698 | - | expression tag |
| His 699 | - | expression tag |
| His 700 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 165247.5 | |
| All* | Total formula weight | 165247.5 |
