4K5Z
Crystal Structure of Human Chymase in Complex with Fragment Inhibitor 6-chloro-2,3-dihydro-1H-isoindol-1-one
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chymase | polymer | 226 | 24991.9 | 1 | UniProt (P23946) Pfam (PF00089) | Homo sapiens (human) | Alpha-chymase, Mast cell protease I |
| 2 | B (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | 6-chloro-2,3-dihydro-1H-isoindol-1-one | non-polymer | 167.6 | 1 | Chemie (1P7) | |||
| 5 | E (A) | water | water | 18.0 | 223 | Chemie (HOH) |
Sequence modifications
A: 16 - 245 (UniProt: P23946)
| PDB | External Database | Details |
|---|---|---|
| Lys 127 | Phe 135 | conflict |
| Ala 208 | Val 212 | conflict |
| Gln 235 | Arg 237 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 24991.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 454.2 | |
| All* | Total formula weight | 25446.1 |
