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4K5Y

Crystal structure of human corticotropin-releasing factor receptor 1 (CRF1R) in complex with the antagonist CP-376395

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B, C
(A, B, C)
Corticotropin-releasing factor receptor 1, T4-Lysozyme chimeric constructpolymer44150429.63UniProt (P34998)
UniProt (P00720)
Pfam (PF00002)
Pfam (PF00959)
HOMO SAPIENS (human)CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, Endolysin Lysis protein, Muramidase
2D, I, R
(A, B, C)
3,6-dimethyl-N-(pentan-3-yl)-2-(2,4,6-trimethylphenoxy)pyridin-4-aminenon-polymer326.53Chemie (1Q5)
3E, S
(A, C)
OLEIC ACIDnon-polymer282.52Chemie (OLA)
4F, G, J
(A, B)
(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoatenon-polymer356.53Chemie (OLC)
5H, O, P, Q
(A, B)
SULFATE IONnon-polymer96.14Chemie (SO4)
6K, L, M
(B)
(1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoatenon-polymer749.03Chemie (PGW)
7N
(B)
PENTAETHYLENE GLYCOLnon-polymer238.31Chemie (1PE)
8T, U
(A, B)
waterwater18.08Chemie (HOH)
Sequence modifications
A, B, C: 104 - 220 (UniProt: P34998)
PDBExternal DatabaseDetails
Met 103-initiating methionine
Ala 120Val 120engineered mutation
Ala 144Leu 144engineered mutation
Ala 156Trp 156engineered mutation
Ala 160Ser 160engineered mutation
A, B, C: 1002 - 1161 (UniProt: P00720)
PDBExternal DatabaseDetails
Ser 1040Asn 1040engineered mutation
Val 1041Ala 1041engineered mutation
Ser 1054Cys 1054engineered mutation
Ser 1097Cys 1097engineered mutation
Ala 1151Thr 1151engineered mutation
A, B, C: 224 - 373 (UniProt: P34998)
PDBExternal DatabaseDetails
Ala 228Lys 228engineered mutation
Ala 260Phe 260engineered mutation
Ala 277Ile 277engineered mutation
Ala 309Tyr 309engineered mutation
Ala 330Phe 330engineered mutation
Ala 349Ser 349engineered mutation
Ala 363Tyr 363engineered mutation
Ala 374-expression tag
Ala 375-expression tag
Ala 376-expression tag
His 377-expression tag
His 378-expression tag
His 379-expression tag
His 380-expression tag
His 381-expression tag
His 382-expression tag
His 383-expression tag
His 384-expression tag
His 385-expression tag
His 386-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight151288.8
Non-Polymers*Number of molecules16
Total formula weight5483.5
All*Total formula weight156772.3
*Water molecules are not included.

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PDB entries from 2024-11-06

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