4K5B

Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Apoptosis regulator BCL-W	polymer	169	18209.6	2		Escherichia coli
2	C, D (C, D)	Bcl-2-like protein 2	polymer	184	20194.5	2	UniProt (Q1RMX3) Pfam (PF02180) Pfam (PF00452)	Bos taurus (bovine cow domestic cattle domestic cow)	Bcl2-L-2, Apoptosis regulator Bcl-W
3	E, F, G, H (A, B, C, D)	water	water		18.0	413	Chemie (HOH)

Sequence modifications

C, D: 13 - 182 (UniProt: Q1RMX3)

PDB	External Database	Details
Met 1	-	expression tag
Arg 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag
Val 128	Pro 117	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	76808.2
All*	Total formula weight	76808.2

*Water molecules are not included.