4K5A

Co-crystallization with conformation-specific designed ankyrin repeat proteins explains the conformational flexibility of BCL-W

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Bcl-2-like protein 2	polymer	184	20194.5	1	UniProt (Q1RMX3) Pfam (PF02180) Pfam (PF00452) In PDB	Bos taurus (bovine cow domestic cattle domestic cow)	Bcl2-L-2, Apoptosis regulator Bcl-W
2	B	Designed Ankyrin Repeat Protein 013_D12	polymer	169	18187.5	1		Escherichia coli
3		water	water		18.0	402	Chemie (HOH)

Sequence modifications

A: 13 - 182 (UniProt: Q1RMX3)

PDB	External Database	Details
Met 1	-	expression tag
Arg 2	-	expression tag
Gly 3	-	expression tag
Ser 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag
Val 128	Pro 117	engineered mutation
Glu 183	-	expression tag
Ala 184	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	38381.9
All*	Total formula weight	38381.9

*Water molecules are not included.