4K24

Structure of anti-uPAR Fab ATN-658 in complex with uPAR

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Urokinase-type plasminogen activator	polymer	135	15359.3	1	UniProt (P00749) Pfam (PF00051) In PDB	Homo sapiens (human)	U-plasminogen activator, uPA, Urokinase-type plasminogen activator long chain A, Urokinase-type plasminogen activator short chain A, Urokinase-type plasminogen activator chain B
2	B	Vitronectin	polymer	40	4573.1	1	UniProt (P04004) Pfam (PF01033) In PDB	Homo sapiens (human)	VN, S-protein, Serum-spreading factor, V75, Vitronectin V65 subunit, Vitronectin V10 subunit, Somatomedin-B
3	H	anti-uPAR antibody, heavy chain	polymer	228	24482.5	1		Mus musculus
4	L	anti-uPAR antibody, light chain	polymer	219	24156.9	1		Mus musculus
5	U	Urokinase plasminogen activator surface receptor	polymer	283	31601.5	1	UniProt (Q03405) Pfam (PF00021) In PDB	Homo sapiens (human)	U-PAR, uPAR, Monocyte activation antigen Mo3
6	C, D	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
7	U	alpha-D-mannopyranose	non-polymer		180.2	1	Chemie (MAN)
8	U	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)

Sequence modifications

A: 1 - 133 (UniProt: P00749)

PDB	External Database	Details
Arg -1	-	expression tag
Ser 0	-	expression tag

U: 1 - 281 (UniProt: Q03405)

PDB	External Database	Details
Arg -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	100173.3
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	2
	Total formula weight	401.4
All*	Total formula weight	101423.5

*Water molecules are not included.