4K1Q

Structure of hCAIX mimic (hCAII with 5 mutations in active site)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Carbonic anhydrase 2	polymer	258	29038.7	1	UniProt (P00918) Pfam (PF00194) In PDB	Homo sapiens (human)	Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II
2	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3		water	water		18.0	225	Chemie (HOH)

Sequence modifications

A: 3 - 261 (UniProt: P00918)

PDB	External Database	Details
Ser 65	Ala 65	engineered mutation
Gln 67	Asn 67	engineered mutation
Thr 69	Glu 69	engineered mutation
Leu 131	Phe 130	engineered mutation
Glu 170	Lys 169	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29038.7
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	29169.5

*Water molecules are not included.