4K1J
Induced opening of influenza virus neuraminidase N2 150-loop suggests an important role in inhibitor binding
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Neuraminidase | polymer | 388 | 42996.7 | 2 | UniProt (Q194T1) Pfam (PF00064) In PDB | Influenza A virus | |
2 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | D, F | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
4 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
5 | A, B | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid | non-polymer | 284.4 | 2 | Chemie (G39) | |||
6 | water | water | 18.0 | 765 | Chemie (HOH) |
Sequence modifications
A, B: 82 - 469 (UniProt: Q194T1)
PDB | External Database | Details |
---|---|---|
Gly 147 | Asp 147 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 85993.5 | |
Branched | Number of molecules | 4 |
Total formula weight | 2346.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 648.9 | |
All* | Total formula weight | 88988.5 |