4K0Z
Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with methazolamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Carbonic anhydrase 2 | polymer | 258 | 29038.7 | 1 | UniProt (P00918) Pfam (PF00194) | Homo sapiens (human) | Carbonate dehydratase II, Carbonic anhydrase C, CAC, Carbonic anhydrase II, CA-II |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, F, G, H (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 5 | Chemie (DMS) | |||
| 4 | I (A) | N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide | non-polymer | 236.3 | 1 | Chemie (MZM) | |||
| 5 | J (A) | water | water | 18.0 | 304 | Chemie (HOH) |
Sequence modifications
A: 3 - 261 (UniProt: P00918)
| PDB | External Database | Details |
|---|---|---|
| Ser 65 | Ala 65 | engineered mutation |
| Gln 67 | Asn 67 | engineered mutation |
| Thr 69 | Glu 69 | engineered mutation |
| Leu 131 | Phe 130 | engineered mutation |
| Glu 170 | Lys 169 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 29038.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 757.8 | |
| All* | Total formula weight | 29796.5 |
