4JZJ
Crystal Structure of Receptor-Fab Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | C, D | Interleukin-3 receptor subunit alpha | polymer | 287 | 33097.4 | 2 | UniProt (P26951) Pfam (PF18611) Pfam (PF09240) In PDB | Homo sapiens (human) | IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA |
2 | A, H | Fab Heavy Chain | polymer | 221 | 23799.9 | 2 | Mus musculus (mouse) | ||
3 | B, L | Fab Light Chain | polymer | 220 | 24256.7 | 2 | Mus musculus (mouse) | ||
4 | E | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-3)][beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1203.1 | 1 | In PDB GlyTouCan (G23711JB) | |||
5 | F | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-3)][beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 878.8 | 1 | In PDB GlyTouCan (G17345YW) | |||
6 | G | alpha-L-fucopyranose-(1-3)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 513.5 | 1 | In PDB GlyTouCan (G08300EX) | |||
7 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
8 | D, H | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
9 | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
C, D: 20 - 306 (UniProt: P26951)
PDB | External Database | Details |
---|---|---|
Lys 144 | Asn 144 | SEE REMARK 999 |
- | Arg 145 | deletion |
Val 298 | Ala 299 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 162308.2 | |
Branched | Number of molecules | 3 |
Total formula weight | 2595.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 626.6 | |
All* | Total formula weight | 165530.2 |