4JY0

Crystal structure of hcv ns5b polymerase in complex with compound 3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Genome polyprotein	polymer	576	64285.6	2	UniProt (O92972)	Hepatitis C virus (HCV)	Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68
2	C, D (A, B)	(4S,5R)-1-(4-tert-butylbenzoyl)-2-(2-methylpropyl)-4-pyrazin-2-yl-5-(1,3-thiazol-2-yl)-L-proline	non-polymer		492.6	2	Chemie (1O9) PubChem (69354634) PubChem (10163588) PubChem (69355494) PubChem (10228346) PubChem (11156123)
3	E, F (A, B)	water	water		18.0	486	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: O92972)

PDB	External Database	Details
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128571.3
Non-Polymers*	Number of molecules	2
	Total formula weight	985.3
All*	Total formula weight	129556.5

*Water molecules are not included.