4JW3
Selection of specific protein binders for pre-defined targets from an optimized library of artificial helicoidal repeat proteins (alphaRep)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Neocarzinostatin | polymer | 120 | 12196.2 | 2 | UniProt (P0A3S0) Pfam (PF00960) In PDB | Streptomyces malayensis | NCS, Mitomalcin, MMC |
2 | C, D | Alpha-helical artificial proteins | polymer | 139 | 15493.6 | 2 | synthetic construct (artificial) | ||
3 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 112 (UniProt: P0A3S0)
PDB | External Database | Details |
---|---|---|
Trp 33 | Asp 33 | engineered mutation |
Ala 35 | Gly 35 | engineered mutation |
Trp 37 | Cys 37 | engineered mutation |
Arg 39 | Trp 39 | engineered mutation |
Trp 45 | Leu 45 | engineered mutation |
Tyr 47 | Cys 47 | engineered mutation |
Asn 52 | Phe 52 | engineered mutation |
Ala 113 | - | expression tag |
Ala 114 | - | expression tag |
His 115 | - | expression tag |
His 116 | - | expression tag |
His 117 | - | expression tag |
His 118 | - | expression tag |
His 119 | - | expression tag |
His 120 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 55379.6 | |
All* | Total formula weight | 55379.6 |