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4JTY

Crystal structure of HCV NS5B polymerase with COMPOUND 2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BGenome polyproteinpolymer57664285.62UniProt (O92972)
Pfam (PF00998)
In PDB
Hepatitis C virus (HCV)Core protein p21, Capsid protein C, p21, Core protein p19, Envelope glycoprotein E1, gp32, gp35, Envelope glycoprotein E2, NS1, gp68, gp70, p7, Protease NS2-3, p23, Serine protease NS3, Hepacivirin, NS3P, p70, Non-structural protein 4A, NS4A, p8, Non-structural protein 4B, NS4B, p27, Non-structural protein 5A, NS5A, p56, RNA-directed RNA polymerase, NS5B, p68
2A, BGLYCEROLnon-polymer92.12Chemie (GOL)
3A, B3-{[4-oxo-1-(2,4,6-trifluorobenzyl)-1,4-dihydroquinazolin-6-yl]oxy}-2-(trifluoromethyl)benzamidenon-polymer493.42Chemie (1NV)
4A, BMAGNESIUM IONnon-polymer24.32Chemie (MG)
5waterwater18.0437Chemie (HOH)
Sequence modifications
A, B: 1 - 570 (UniProt: O92972)
PDBExternal DatabaseDetails
His 571-expression tag
His 572-expression tag
His 573-expression tag
His 574-expression tag
His 575-expression tag
His 576-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight128571.3
Non-Polymers*Number of molecules6
Total formula weight1219.5
All*Total formula weight129790.8
*Water molecules are not included.

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PDB entries from 2024-07-10

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