4JTH
Crystal structure of F114R/R117Q mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | 2-dehydro-3-deoxyphosphooctonate aldolase | polymer | 280 | 30500.3 | 4 | UniProt (Q9JZ55) Pfam (PF00793) | Neisseria meningitidis | 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase |
| 2 | E, F, G, I, J (B, C, D) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 3 | H (C) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | K (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 795 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 280 (UniProt: Q9JZ55)
| PDB | External Database | Details |
|---|---|---|
| Arg 114 | Phe 114 | engineered mutation |
| Gln 117 | Arg 117 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 122001.1 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 292.3 | |
| All* | Total formula weight | 122293.5 |
