4JTG

Crystal structure of F114R/R117A mutant of 3-deoxy-D-manno-octulosonate 8-phosphate synthase (KDO8PS) from Neisseria meningitidis

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	2-dehydro-3-deoxyphosphooctonate aldolase	polymer	280	30443.2	4	UniProt (Q9JZ55) Pfam (PF00793)	Neisseria meningitidis	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase, KDO-8-phosphate synthase, KDO 8-P synthase, KDOPS, Phospho-2-dehydro-3-deoxyoctonate aldolase
2	E, F, G, I, J... (A, B, C, D)	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
3	H (C)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
4	L (D)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
5	M, N, O, P (A, B, C, D)	water	water		18.0	790	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 280 (UniProt: Q9JZ55)

PDB	External Database	Details
Arg 114	Phe 114	engineered mutation
Ala 117	Arg 117	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	121772.9
Non-Polymers*	Number of molecules	8
	Total formula weight	327.8
All*	Total formula weight	122100.7

*Water molecules are not included.