4JSR
Crystal Structure of human SIRT3 with ELT inhibitor 11c [N-{2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl}-N'-ethylthiophene-2,5-dicarboxamide]
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | polymer | 285 | 31612.3 | 1 | UniProt (Q9NTG7) Pfam (PF02146) | Homo sapiens (human) | hSIRT3, Regulatory protein SIR2 homolog 3, SIR2-like protein 3 |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | N-{2-[1-(6-carbamoylthieno[3,2-d]pyrimidin-4-yl)piperidin-4-yl]ethyl}-N'-ethylthiophene-2,5-dicarboxamide | non-polymer | 486.6 | 1 | Chemie (1NQ) | |||
| 4 | D (A) | water | water | 18.0 | 306 | Chemie (HOH) |
Sequence modifications
A: 118 - 399 (UniProt: Q9NTG7)
| PDB | External Database | Details |
|---|---|---|
| Ser 115 | - | expression tag |
| Asn 116 | - | expression tag |
| Ala 117 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31612.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 552.0 | |
| All* | Total formula weight | 32164.4 |
