4JR1

Human procaspase-7 bound to Ac-DEVD-CMK

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Procaspase-7	polymer	250	28315.2	2	UniProt (P55210) Pfam (PF00656)	Homo sapiens (human)	CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7
2	C, D (C, D)	Ac-DEVD-CMK	polymer	6	537.0	2	BIRD (PRD_000924)
3	E, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	G, H, I (A, B, D)	water	water		18.0	203	Chemie (HOH)

Sequence modifications

A, B: 57 - 303 (UniProt: P55210)

PDB	External Database	Details
Ser 54	-	expression tag
Asn 55	-	expression tag
Ala 56	-	expression tag
Ala 198	Asp 198	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57704.3
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	57775.2

*Water molecules are not included.