4JR0

Human procaspase-3 bound to Ac-DEVD-CMK

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Procaspase-3	polymer	247	28303.3	2	UniProt (P42574) Pfam (PF00656)	Homo sapiens (human)	CASP-3, Apopain, Cysteine protease CPP32, CPP-32, Protein Yama, SREBP cleavage activity 1, SCA-1, Caspase-3
2	C, D (C, D)	Ac-DEVD-CMK	polymer	6	537.0	2	BIRD (PRD_000924)
3	E, F (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
4	G, H, I, J (A, B, C, D)	water	water		18.0	423	Chemie (HOH)

Sequence modifications

A, B: 34 - 277 (UniProt: P42574)

PDB	External Database	Details
Ser 31	-	expression tag
Asn 32	-	expression tag
Ala 33	-	expression tag
Ala 175	Asp 175	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	57680.4
Non-Polymers*	Number of molecules	2
	Total formula weight	70.9
All*	Total formula weight	57751.3

*Water molecules are not included.