4JQA

AKR1C2 complex with mefenamic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Aldo-keto reductase family 1 member C2	polymer	331	37857.4	2	UniProt (P52895) Pfam (PF00248) In PDB	Homo sapiens (human)	3-alpha-HSD3, Chlordecone reductase homolog HAKRD, Dihydrodiol dehydrogenase 2, DD-2, DD2, Dihydrodiol dehydrogenase/bile acid-binding protein, DD/BABP, Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase, Type III 3-alpha-hydroxysteroid dehydrogenase
2	A, B	2-[(2,3-DIMETHYLPHENYL)AMINO]BENZOIC ACID	non-polymer		241.3	2	Chemie (ID8)
3	A, B	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		743.4	2	Chemie (NAP)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	4	Chemie (EDO)
5	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
6	B	L(+)-TARTARIC ACID	non-polymer		150.1	1	Chemie (TLA)
7	B	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
8		water	water		18.0	501	Chemie (HOH)

Sequence modifications

A, B: 1 - 323 (UniProt: P52895)

PDB	External Database	Details
Leu 324	-	expression tag
Glu 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75714.8
Non-Polymers*	Number of molecules	11
	Total formula weight	2485.7
All*	Total formula weight	78200.5

*Water molecules are not included.