4JOA
Crystal Structure of Human Anaplastic Lymphoma Kinase in complex with 7-azaindole based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 344 | 38641.3 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (human) | Anaplastic lymphoma kinase |
| 2 | B (A) | 3-[1-(2,5-difluorobenzyl)-1H-pyrazol-4-yl]-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine | non-polymer | 390.4 | 1 | Chemie (3DK) | |||
| 3 | C (A) | water | water | 18.0 | 26 | Chemie (HOH) |
Sequence modifications
A: 1072 - 1410 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1067 | - | expression tag |
| Ala 1068 | - | expression tag |
| Met 1069 | - | expression tag |
| Gly 1070 | - | expression tag |
| Ser 1071 | - | expression tag |
| Gly 1281 | Ser 1281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38641.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 390.4 | |
| All* | Total formula weight | 39031.7 |
