4JM2
Crystal Structure of PGT 135 Fab in Complex with gp120 Core Protein from HIV-1 Strain JR-FL Bound to CD4 and 17b Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PGT 135 Heavy chain | polymer | 236 | 25575.8 | 1 | Homo sapiens (human) | ||
| 2 | B | PGT 135 Light chain | polymer | 214 | 23795.5 | 1 | Homo sapiens (human) | ||
| 3 | C | 17b Light chain | polymer | 214 | 23399.9 | 1 | Homo sapiens (human) | ||
| 4 | D | 17b Heavy chain | polymer | 229 | 24457.4 | 1 | Homo sapiens (human) | ||
| 5 | E | gp120 | polymer | 321 | 35991.9 | 1 | Pfam (PF00516) UniProt (by SIFTS) (Q75760) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
| 6 | F | T-cell surface glycoprotein CD4 | polymer | 185 | 20503.3 | 1 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB | Homo sapiens (human) | T-cell surface antigen T4/Leu-3 |
| 7 | G | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1397.2 | 1 | In PDB GlyTouCan (G80966KZ) | |||
| 8 | H | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G40702WU) | |||
| 9 | I | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 10 | C | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 11 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 12 | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
F: 1 - 183 (UniProt: P01730)
| PDB | External Database | Details |
|---|---|---|
| Asn 184 | - | expression tag |
| Thr 185 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 153723.7 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 3705.3 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1521.5 | |
| All* | Total formula weight | 158950.5 |
