4JLG
SETD7 in complex with inhibitor (R)-PFI-2 and S-adenosyl-methionine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Histone-lysine N-methyltransferase SETD7 | polymer | 264 | 29684.0 | 2 | UniProt (Q8WTS6) Pfam (PF22648) Pfam (PF00856) | Homo sapiens (human) | Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, Lysine N-methyltransferase 7, SET domain-containing protein 7, SET7/9 |
| 2 | C, V (A, B) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 2 | Chemie (SAM) | |||
| 3 | D, W (A, B) | 8-fluoro-N-{(2R)-1-oxo-1-(pyrrolidin-1-yl)-3-[3-(trifluoromethyl)phenyl]propan-2-yl}-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide | non-polymer | 499.5 | 2 | Chemie (1L8) | |||
| 4 | AA, BA, CA, DA, E... (B, A) | UNKNOWN ATOM OR ION | non-polymer | 25 | Chemie (UNX) | ||||
| 5 | FA, GA (A, B) | water | water | 18.0 | 394 | Chemie (HOH) |
Sequence modifications
A, B: 109 - 366 (UniProt: Q8WTS6)
| PDB | External Database | Details |
|---|---|---|
| His 367 | - | expression tag |
| His 368 | - | expression tag |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59367.9 | |
| Non-Polymers* | Number of molecules | 29 |
| Total formula weight | 1795.9 | |
| All* | Total formula weight | 61163.8 |
