4JKD
Open and closed forms of I1790Y human PRP8 RNase H-like domain with bound Mg ion
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pre-mRNA-processing-splicing factor 8 | polymer | 222 | 25588.8 | 2 | UniProt (Q6P2Q9) Pfam (PF12134) | Homo sapiens | 220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220 |
| 2 | C, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 3 | D, E, G, H (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 4 | I, J (A, B) | water | water | 18.0 | 688 | Chemie (HOH) |
Sequence modifications
A, B: 1769 - 1990 (UniProt: Q6P2Q9)
| PDB | External Database | Details |
|---|---|---|
| Tyr 1790 | Ile 1790 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51177.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 190.4 | |
| All* | Total formula weight | 51368.0 |
