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4JK7

Open and closed forms of wild-type human PRP8 RNase H-like domain with bound Mg ion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Pre-mRNA-processing-splicing factor 8polymer22225538.82UniProt (Q6P2Q9)
Pfam (PF12134)
Homo sapiens (human)220 kDa U5 snRNP-specific protein, PRP8 homolog, Splicing factor Prp8, p220
2C, D
(A)
GLYCEROLnon-polymer92.12Chemie (GOL)
3E, F, G, J, K
(A, B)
CHLORIDE IONnon-polymer35.55Chemie (CL)
4H, I
(B)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
5L, M
(A, B)
waterwater18.0692Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight51077.6
Non-Polymers*Number of molecules9
Total formula weight410.1
All*Total formula weight51487.6
*Water molecules are not included.

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PDB entries from 2025-06-11

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