4JDK

Crystal structure of Serine/threonine-protein kinase PAK 4 F461V mutant in complex with Paktide S peptide substrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Serine/threonine-protein kinase PAK 4	polymer	346	39155.1	1	UniProt (O96013) Pfam (PF00069) In PDB	Homo sapiens (human)	p21-activated kinase 4, PAK-4
2	B	Paktide S	polymer	7	1083.3	1
3		water	water		18.0	49	Chemie (HOH)

Sequence modifications

A: 286 - 591 (UniProt: O96013)

PDB	External Database	Details
Met 246	-	expression tag
Gly 247	-	expression tag
Ser 248	-	expression tag
Ser 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
His 254	-	expression tag
His 255	-	expression tag
Ser 256	-	expression tag
Ser 257	-	expression tag
Gly 258	-	expression tag
Leu 259	-	expression tag
Val 260	-	expression tag
Pro 261	-	expression tag
Arg 262	-	expression tag
Gly 263	-	expression tag
Ser 264	-	expression tag
His 265	-	expression tag
Met 266	-	expression tag
Glu 267	-	expression tag
Asn 268	-	expression tag
Leu 269	-	expression tag
Tyr 270	-	expression tag
Phe 271	-	expression tag
Gln 272	-	expression tag
Gly 273	-	expression tag
Ala 274	-	expression tag
Arg 275	-	expression tag
Ala 276	-	expression tag
Arg 277	-	expression tag
Gln 278	-	expression tag
Glu 279	-	expression tag
Asn 280	-	expression tag
Gly 281	-	expression tag
Met 282	-	expression tag
Pro 283	-	expression tag
Glu 284	-	expression tag
Lys 285	-	expression tag
Val 461	Phe 461	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	40238.3
All*	Total formula weight	40238.3

*Water molecules are not included.