4JBO
Novel Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aurora kinase A | polymer | 279 | 32359.1 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2, Aurora/IPL1-related kinase 1, ARK-1, Aurora-related kinase 1, hARK1, Breast tumor-amplified kinase, Serine/threonine-protein kinase 15, Serine/threonine-protein kinase 6, Serine/threonine-protein kinase aurora-A |
| 2 | B (A) | 1-(4-{2-[(6-{4-[2-(dimethylamino)ethoxy]phenyl}furo[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea | non-polymer | 536.6 | 1 | Chemie (WPH) | |||
| 3 | C (A) | water | water | 18.0 | 20 | Chemie (HOH) |
Sequence modifications
A: 123 - 401 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Asp 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32359.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 536.6 | |
| All* | Total formula weight | 32895.7 |
