4J71
Crystal Structure of GSK3b in complex with inhibitor 1R
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Glycogen synthase kinase-3 beta | polymer | 424 | 47179.5 | 2 | UniProt (P49841) Pfam (PF00069) | Homo sapiens (human) | GSK-3 beta, Serine/threonine-protein kinase GSK3B |
| 2 | C, G (A, B) | (2R)-2-methyl-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one | non-polymer | 163.2 | 2 | Chemie (1JX) | |||
| 3 | D, E, H (A, B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | F (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 420 (UniProt: P49841)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Pro -1 | - | expression tag |
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 94359.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 650.0 | |
| All* | Total formula weight | 95009.0 |
