4IZA

Structure of Dually Phosphorylated ERK2 bound to the PEA-15 Death Effector Domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Mitogen-activated protein kinase 1	polymer	356	41258.2	2	UniProt (P28482) Pfam (PF00069)	Homo sapiens (human)	MAP kinase 1, MAPK 1, ERT1, Extracellular signal-regulated kinase 2, ERK-2, MAP kinase isoform p42, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2
2	C (B)	Astrocytic phosphoprotein PEA-15	polymer	97	11238.5	1	UniProt (Q15121) Pfam (PF01335)	Homo sapiens (human)	15 kDa phosphoprotein enriched in astrocytes, Phosphoprotein enriched in diabetes, PED
3	D, E, F (A, C, B)	water	water		18.0	633	Chemie (HOH)

Sequence modifications

A, C: 8 - 360 (UniProt: P28482)

PDB	External Database	Details
Gly 5	-	expression tag
Pro 6	-	expression tag
Gly 7	-	expression tag

B: 1 - 96 (UniProt: Q15121)

PDB	External Database	Details
Gly 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	93754.8
All*	Total formula weight	93754.8

*Water molecules are not included.