4IZ0

Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RNA-directed RNA polymerase	polymer	576	64285.6	2	UniProt (O92972) Pfam (PF00998)	Hepatitis C virus (HCV)	NS5B, p68
2	C, D (A)	2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide	non-polymer		341.6	2	Chemie (2BI)
3	E (A)	water	water		18.0	4	Chemie (HOH)

Sequence modifications

A, B: 1 - 570 (UniProt: O92972)

PDB	External Database	Details
His 571	-	expression tag
His 572	-	expression tag
His 573	-	expression tag
His 574	-	expression tag
His 575	-	expression tag
His 576	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	128571.3
Non-Polymers*	Number of molecules	2
	Total formula weight	683.2
All*	Total formula weight	129254.5

*Water molecules are not included.