4IWC
Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with a Dynamic Thiophene-derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 247 | 28189.2 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 10 | 1276.5 | 2 | UniProt (Q15596) | Homo sapiens | NCoA-2, Class E basic helix-loop-helix protein 75, bHLHe75, Transcriptional intermediary factor 2, hTIF2 |
| 3 | E, F (A, B) | 4,4'-thiene-2,5-diylbis(3-methylphenol) | non-polymer | 296.4 | 2 | Chemie (1GV) | |||
| 4 | G, H, I (A, B, C) | water | water | 18.0 | 178 | Chemie (HOH) |
Sequence modifications
A, B: 303 - 549 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58931.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 592.8 | |
| All* | Total formula weight | 59524.3 |
