4ITJ
Crystal structure of RIP1 kinase in complex with necrostatin-4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Receptor-interacting serine/threonine-protein kinase 1 | polymer | 294 | 33468.7 | 2 | UniProt (Q13546) Pfam (PF07714) | Homo sapiens (human) | Cell death protein RIP, Receptor-interacting protein 1, RIP-1, Serine/threonine-protein kinase RIP |
| 2 | C, I (A, B) | N-[(1S)-1-(2-chloro-6-fluorophenyl)ethyl]-5-cyano-1-methyl-1H-pyrrole-2-carboxamide | non-polymer | 305.7 | 2 | Chemie (1HX) | |||
| 3 | D, E, F, G, H... (A, B) | IODIDE ION | non-polymer | 126.9 | 9 | Chemie (IOD) | |||
| 4 | N, O (A, B) | water | water | 18.0 | 578 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 294 (UniProt: Q13546)
| PDB | External Database | Details |
|---|---|---|
| Ala 34 | Cys 34 | engineered mutation |
| Ala 127 | Cys 127 | engineered mutation |
| Ala 233 | Cys 233 | engineered mutation |
| Ala 240 | Cys 240 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66937.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1753.6 | |
| All* | Total formula weight | 68691.1 |
